Links: BOTTOM PredictProtein Burkhard Rost




Results from PredictProtein for t1

TOC for file t1

  1. The following information has been received by the server (TOC)
  2. MAXHOM alignment header (TOC)
  3. MAXHOM alignment (TOC)
  4. PHD information about accuracy (TOC)
  5. PHD predictions (TOC)
  6. GLOBE prediction of globularity (TOC)

END of TOC




BEG of results for file t1


The following information has been received by the server


rost@columbia.edu
ret concise
ret no prodom
ret no prosite
ret no coils
ret no seg
ret html 60
# paho_chick
MPPRWASLLL LACSLLLLAV PPGTAGPSQP TYPGDDAPVE DLIRFYNDLQ
QYLNVVTRHR YGRRSSSRVL CEEPMGAAGC


MAXHOM alignment header


--- ------------------------------------------------------------
--- MAXHOM multiple sequence alignment
--- ------------------------------------------------------------
--- 
--- MAXHOM ALIGNMENT HEADER: ABBREVIATIONS FOR SUMMARY
--- ID           : identifier of aligned (homologous) protein
--- STRID        : PDB identifier (only for known structures)
--- PIDE         : percentage of pairwise sequence identity
--- WSIM         : percentage of weighted similarity
--- LALI         : number of residues aligned
--- NGAP         : number of insertions and deletions (indels)
--- LGAP         : number of residues in all indels
--- LSEQ2        : length of aligned sequence
--- ACCNUM       : SwissProt accession number
--- NAME         : one-line description of aligned protein
--- 
--- MAXHOM ALIGNMENT HEADER: SUMMARY
ID         STRID  IDE WSIM LALI NGAP LGAP LEN2 ACCNUM NAME                     
paho_chick 1PPT   100  100   80    0    0   80 P01306 PANCREATIC HORMONE PRECUR
paho_larar         94   97   36    0    0   36 P41337 PANCREATIC HORMONE (PANCR
paho_strca         89   96   36    0    0   36 P11967 PANCREATIC HORMONE (PANCR
paho_allmi         80   87   35    0    0   36 P06305 PANCREATIC HORMONE (PANCR
paho_ansan         72   73   36    0    0   36 P06304 PANCREATIC HORMONE (PANCR
neuy_sheep         60   78   35    0    0   36 P14765 NEUROPEPTIDE Y (NPY).    
neuy_human 1RON    46   64   69    0    0   97 P01303 NEUROPEPTIDE Y PRECURSOR 
neuy_chick         45   65   71    0    0   97 P28673 NEUROPEPTIDE Y PRECURSOR 
neuy_pig           56   76   35    0    0   36 P01304 NEUROPEPTIDE Y (NPY).    
neuy_rat           45   63   67    0    0   98 P07808 NEUROPEPTIDE Y PRECURSOR 
neuy_xenla         42   62   69    0    0   97 P33689 NEUROPEPTIDE Y PRECURSOR.
pyy_pig            54   73   35    0    0   36 P01305 PEPTIDE YY (PYY).        
neuy_rabit         54   75   35    0    0   36 P09640 NEUROPEPTIDE Y (NPY).    
paho_canfa         41   52   71    1    1   93 P01299 PANCREATIC HORMONE PRECUR
npy_lamfl          40   53   70    1    3  104 P48097 NEUROPEPTIDE Y PRECURSOR 
pyy_rat            39   53   75    1    2   98 P10631 PEPTIDE YY PRECURSOR (PYY
paho_human         39   54   72    1    2   95 P01298 PANCREATIC HORMONE PRECUR
neuy_ranri         51   73   35    0    0   36 P29949 (NPY).                   
pyy_amica          51   72   35    0    0   36 P29205 PEPTIDE YY-LIKE (PYY).   
neuy_torma         38   57   71    0    0   98 P28674 NEUROPEPTIDE Y PRECURSOR 
paho_rat           39   49   67    2    8   98 P06303 PANCREATIC HORMONE PRECUR
paho_mouse         38   50   69    2    6  100 P10601 PANCREATIC HORMONE PRECUR
pyy_human          35   52   79    0    0   97 P10082 PEPTIDE YY PRECURSOR (PYY
pyy_lamfl          38   50   63    1    1   93 P48098 PEPTIDE YY HOMOLOG PRECUR
paho_bovin 1BBA    35   49   77    1    2  131 P01302 PANCREATIC HORMONE PRECUR
paho_rante         49   66   35    0    0   36 P31229 PANCREATIC HORMONE (PANCR
paho_rabit         49   68   35    0    0   36 P41336 PANCREATIC HORMONE (PANCR
pyy_rajrh          49   71   35    0    0   36 P29206 PEPTIDE YY-LIKE (PYY).   
pyy_lepsp          49   71   35    0    0   36 P09473 PEPTIDE YY-LIKE (PYY) (NE
pyy_oncki          49   70   35    0    0   36 P09474 PEPTIDE YY-LIKE (PYY).   
neuy_oncmy         49   70   35    0    0   36 P29071 NEUROPEPTIDE Y (NPY).    
pyy_bovin          36   54   67    0    0   97 P51694 PEPTIDE YY PRECURSOR (PYY
paho_cavpo         37   52   63    1    3  126 P13083 PANCREATIC HORMONE PRECUR
neuy_carau         34   52   71    0    0   96 P28672 NEUROPEPTIDE Y PRECURSOR 
paho_didma         46   66   35    0    0   36 P18107 PANCREATIC HORMONE (PANCR
paho_macmu         46   66   35    0    0   36 P33684 PANCREATIC HORMONE (PANCR
paho_ranca         46   64   35    0    0   36 P15427 PANCREATIC HORMONE (PANCR
neuy_gadmo         46   69   35    0    0   36 P80167 NEUROPEPTIDE Y (NPY).    
paho_pig           46   66   35    0    0   36 P01300 PANCREATIC HORMONE (PANCR
pyy_chick          43   65   37    0    0   37 P29203 PEPTIDE YY-LIKE (PYY).   
paho_felca         37   56   52    0    0   66 P06884 PANCREATIC HORMONE PRECUR
paho_sheep         36   57   50    0    0   59 P01301 PANCREATIC HORMONE PRECUR
paho_equze         43   65   35    0    0   36 P38000 PANCREATIC HORMONE (PANCR
paho_erieu         43   65   35    0    0   36 P41335 PANCREATIC HORMONE (PANCR
paho_tappi         43   65   35    0    0   36 P39659 PANCREATIC HORMONE (PANCR
pyy_ranri          43   65   35    0    0   36 P29204 PEPTIDE YY-LIKE (PYY).   
spyy_phybi         43   65   35    0    0   36 P80952 SKIN PEPTIDE TYROSINE-TYR
paho_cersi         43   65   35    0    0   36 P37999 PANCREATIC HORMONE (PANCR
ppy_lopam          40   56   40    0    0   69 P09475 PANCREATIC POLYPEPTIDE YG
--- 
--- MAXHOM ALIGNMENT: IN MSF FORMAT


--- ------------------------------------------------------------
--- 3D homologue: the known structure that appeared to have sig-
--- 3D homologue: nificant sequence identity to your protein is:
--- 3D homologue: 1PPT, 1RON, 1BBA, 
.
--- 3D homologue: Note: we do  NOT  check whether the similarity
--- 3D homologue:       is in the region for which structure has
--- 3D homologue:       been determined.  Thus, please verify!  
--- ------------------------------------------------------------

--- 
--- Version of database searched for alignment:
--- SWISS-PROT release 38.0 (7/99) with 80000 proteins
--- 

MAXHOM alignment


TOP - BOTTOM - MaxHom - MView
Identities computed with respect to: (1) t10
Colored by: consensus/70% and sequence
                          1 [        .         .         .         .         :         .         .         ] 80
 1 t10            100.0%    MPPRWASLLLLACSLLLLAVPPGTAGPSQPTYPGDDAPVEDLIRFYNDLQQYLNVVTRHRYGRRSSSRVLCEEPMGAAGC   
 2 paho_chick     100.0%    MPPRWASLLLLACSLLLLAVPPGTAGPSQPTYPGDDAPVEDLIRFYNDLQQYLNVVTRHRYGRRSSSRVLCEEPMGAAGC   
 3 paho_larar      94.4%    -------------------------GPVQPTYPGDDAPVEDLVRFYNDLQQYLNVVTRHRY-------------------   
 4 paho_strca      88.9%    -------------------------GPAQPTYPGDDAPVEDLVRFYDNLQQYLNVVTRHRY-------------------   
 5 paho_allmi      80.0%    --------------------------PLQPKYPGDGAPVEDLIQFYDDLQQYLNVVTRPRF-------------------   
 6 paho_ansan      72.2%    -------------------------GPSQPTYPGNDAPVEDLRFYYDNLQQYRLNVFRHRY-------------------   
 7 neuy_sheep      60.0%    --------------------------PSKPDNPGDDAPAEDLARYYSALRHYINLITRQRY-------------------   
 8 neuy_human      46.4%    ------SGLTLALSLLVCLGALAEAYPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYGKRSSPETLISDLL-----   
 9 neuy_chick      45.1%    ----WVSVLTFALSLLICLGTLAEAYPSKPDSPGEDAPAEDMARYYSALRHYINLITRQRYGKRSSPETLISDLL-----   
10 neuy_pig        57.1%    --------------------------PSKPDNPGEDAPAEDLARYYSALRHYINLITRQRY-------------------   
11 neuy_rat        44.8%    --------LTLALSLLVCLGILAEGYPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYGKRSSPETLISDLL-----   
12 neuy_xenla      42.0%    ----WMSVLTLCLSMLICLGTFAEAYPSKPDNPGEDAPAEDMAKYYSALRHYINLITRQRYGKRSSPETMLSD-------   
13 pyy_pig         54.3%    --------------------------PAKPEAPGEDASPEELSRYYASLRHYLNLVTRQRY-------------------   
14 neuy_rabit      54.3%    --------------------------PSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY-------------------   
15 paho_canfa      39.4%    -------LLLSACVALLLQPPLgrGAPLEPVYPGDDATPEQMAQYAAELRRYINMLTRPRYGKRDRGEMRDILEWGSP--   
16 npy_lamfl       38.6%    -----ARVWLCAIALCLLaaRGAAAFPNKPDSPGEDAPAEDLARYLSAVRHYINLITRQRYGKRTLTEPYVPEFI-----   
17 pyy_rat         37.3%    VAVRRPWPVMVAMLLVLLagALVDAYPAKPEAPGEDASPEELSRYYASLRHYLNLVTRQRYGKREVPAALFSKLL-----   
18 paho_human      38.9%    ------SLLLLStaLLLQPLLGAQGAPLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRYGKRHKEDTLAFSEWGSP--   
19 neuy_ranri      51.4%    --------------------------PSKPDNPGEDAPAEDMAKYYSALRHYINLITRQRY-------------------   
20 pyy_amica       51.4%    --------------------------PPKPENPGEDAPPEELARYYTALRHYINLITRQRY-------------------   
21 neuy_torma      38.0%    ----WLGVFTFAFCMLICIGTFADAYPSKPDNPGEGAPAEDLAKYYSALRHYINLITRQRYGKRSSPEALMMTDL-----   
22 paho_rat        35.6%    ------SLFLLStaLLLQPLQGAWGAPLEPMYPGDYATHEQRAQYETQLRRYINTLTRPRYGKRDE------DTAGLPG-   
23 paho_mouse      35.6%    ------SLFLVStaLLLQPLQGTWGAPLEPMYPGDYATPEQMAQYETQLRRYINTLTRPRYGKRAEE----ENTGGLPG-   
24 pyy_human       35.4%    VRRPWPALTTVLLALLVCLGALVDAYPIKPEAPGEDASPEELNRYYASLRHYLNLVTRQRYGKRDGPDTLLSKTFFPDG-   
25 pyy_lamfl       37.5%    ---RLAALALSVCAILCLGMHA-SAFPPKPDNPGDNASPEQMARYKAAVRHYINLITRQRYGKRALT-------------   
26 paho_bovin      35.1%    -AHRCLFLLLLStaLLLQPPLGALGAPLEPEYPGDNATPEQMAQYAAELRRYINMLTRPRYGKRDKEGTLDFLECGSP--   
27 paho_rante      48.6%    --------------------------PSEPHHPGDQATQDQLAQYYSDLYQYITFVTRPRF-------------------   
28 paho_rabit      48.6%    --------------------------PPEPVYPGDDATPEQMAEYVADLRRYINMLTRPRY-------------------   
29 pyy_rajrh       48.6%    --------------------------PPKPENPGDDAAPEELAKYYSALRHYINLITRQRY-------------------   
30 pyy_lepsp       48.6%    --------------------------PPKPENPGEDAPPEELAKYYSALRHYINLITRQRY-------------------   
31 pyy_oncki       48.6%    --------------------------PPKPENPGEDAPPEELAKYYTALRHYINLITRQRY-------------------   
32 neuy_oncmy      48.6%    --------------------------PVKPENPGEDAPTEELAKYYTALRHYINLITRQRY-------------------   
33 pyy_bovin       35.8%    ---SWPAMATVLLTLLVCLGELVDAYPAKPQAPGEHASPDELNRYYTSLRHYLNLVTRQRFGKRDFSEAL----------   
34 paho_cavpo      34.8%    ----WLLLLGTCMALLL---PEAWGAPLEPVYPGDDATPQQMAQYAAEMRRYINMLTRPRYGKSAEEDAL----------   
35 neuy_carau      33.8%    ----WTGWAACAFLLFVCLGTLTEGYPTKPDNPGEGAPAEELAKYYSALRHYINLITRQRYGKRSSADTLISDLL-----   
36 paho_didma      45.7%    --------------------------PQEPVYPGDDATPEQMAKYAAELRRYINRLTRPRY-------------------   
37 paho_macmu      45.7%    --------------------------PLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRY-------------------   
38 paho_ranca      45.7%    --------------------------PSEPHHPGDQATPDQLAQYYSDLYQYITFITRPRF-------------------   
39 neuy_gadmo      45.7%    --------------------------PIKPENPGEDAPADELAKYYSALRHYINLITRQRY-------------------   
40 paho_pig        45.7%    --------------------------PLEPVYPGDDATPEQMAQYAAELRRYINMLTRPRY-------------------   
41 pyy_chick       43.2%    ------------------------AYPPKPESPGDAASPEEIAQYFSALRHYINLVTRQRY-------------------   
42 paho_felca      36.5%    --------------------------PLEPVYPGDNATPEQMAQYAAELRRYINMLTRPRYGKRDRGETLDILEWGSP--   
43 paho_sheep      36.0%    ----------------------------EPEYPGDNATPEQMAQYAAELRRYINMLTRPRYGKRDKEGTLDFLECGSP--   
44 paho_equze      42.9%    --------------------------PMEPVYPGDNATPEQMAQYAAELRRYINMLTRPRY-------------------   
45 paho_erieu      42.9%    --------------------------PLEPVYPGDNATPEQMAHYAAELRRYINMLTRPRY-------------------   
46 paho_tappi      42.9%    --------------------------PLEPVYPGDNATPEQMAQYAAELRRYINMLTRPRY-------------------   
47 pyy_ranri       42.9%    --------------------------PPKPENPGEDASPEEMTKYLTALRHYINLVTRQRY-------------------   
48 spyy_phybi      42.9%    --------------------------PPKPESPGEDASPEEMNKYLTALRHYINLVTRQRY-------------------   
49 paho_cersi      42.9%    --------------------------PLEPVYPGDNATPEEMAQYAAELRRYINMLTRPRY-------------------   
50 ppy_lopam       40.0%    --------------------------PPKPETPGSNASPEDWASYQAAVRHYVNLITRQRYGXXSS--------------   
   consensus/100%           ............................pP..PGp.As.pph..a.sth.pYh..lhR.Ra...................   
   consensus/90%               .......................P.pP..PG-sAssEphspYhstLppYlNhlTR.RY.................     
   consensus/80%                ......................P.cP..PG-sAssEphupYhstLR+YlNhlTR.RY..............        
   consensus/70%                  ....................P.cPp.PG-sAssEphApYhusLR+YINhlTR.RY..............        


PHD information about accuracy


****************************************************************************
*                                                                          *
*    PHD: Profile fed neural network systems from HeiDelberg               *
*    ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~               *
*                                                                          *
*    Prediction of:			                                   *
* 	secondary structure,   			   by PHDsec		   *
* 	solvent accessibility, 			   by PHDacc		   *
* 	and helical transmembrane regions, 	   by PHDhtm		   *
*                                                                          *
*    Author:             						   *
*	Burkhard Rost							   *
*       EMBL, 69012 Heidelberg, Germany					   *
*       Internet: Rost@EMBL-Heidelberg.DE				   *
*                                                                          *
*    All rights reserved.                                                  *
*                                                                          *
****************************************************************************
*                                                                          *
*    The network systems are described in:   	                     	   *
*                                                                          *
*    PHDsec:    B Rost & C Sander: JMB, 1993, 232, 584-599.		   *
*    		B Rost & C Sander: Proteins, 1994, 19, 55-72.		   *
*    PHDacc:  	B Rost & C Sander: Proteins, 1994, 20, 216-226.		   *
*    PHDhtm:  	B Rost et al.: 	   Prot. Science, 1995, 4, 521-533.	   *
*                                                                          *
****************************************************************************


PHD predictions


TOP - BOTTOM - PHD

PHD predictions for t1

Different levels of data:
  1. PHD brief
  2. PHD normal







AA : amino acid sequence
PHD_sec: PHD predicted secondary structure: H=helix, E=extended (sheet), blank=other (loop)
PHD = PHD: Profile network prediction HeiDelberg
Rel_sec: reliability index for PHDsec prediction (0=low to 9=high)
Note: for the brief presentation strong predictions marked by '*'
SUB_sec: subset of the PHDsec prediction, for all residues with an expected average accuracy > 82% (tables in header)
NOTE: for this subset the following symbols are used:
L: is loop (for which above ' ' is used)
.: means that no prediction is made for this residue, as the reliability is: Rel < 5
pH_sec: 'probability' for assigning helix (1=high, 0=low)
pE_sec: 'probability' for assigning strand (1=high, 0=low)
pL_sec: 'probability' for assigning neither helix, nor strand (1=high, 0=low)
P_3_acc: PHD predicted relative solvent accessibility (acc) in 3 states: b = 0-9%, i = 9-36%, e = 36-100%.
Rel_acc: reliability index for PHDacc prediction (0=low to 9=high)
Note: for the brief presentation strong predictions marked by '*'
SUB_acc: subset of the PHDacc prediction, for all residues with an expected average correlation > 0.69 (tables in header)
NOTE: for this subset the following symbols are used:
I: is intermediate (for which above ' ' is used)
.: means that no prediction is made for this residue, as the reliability is: Rel < 4
PHD_acc: PHD predicted relative solvent accessibility (acc) in 10 states: a value of n (=0-9) corresponds to a relative acc. of between n*n % and (n+1)*(n+1) % (e.g. for n=5: 16-25%).




PHD results (brief)

....,....1....,....2....,....3....,....4....,....5....,....6....,....7....,....8 AA MPPRWASLLLLACSLLLLAVPPGTAGPSQPTYPGDDAPVEDLIRFYNDLQQYLNVVTRHRYGRRSSSRVLCEEPMGAAGC PHD_sec HHHHHHHHHHHHHH HHHHHHHHHHHHHHHHH Rel_sec ** ************ ******************* **************** ************* ******** P_3_acc eeeebbbbbbbbbbbbbbeeeebee eeeee eeeebeeeebbebbbbb bbbbbbbbe bbeeeeeebbeeeeebeeee Rel_acc * * * ****** * * * ** **


PHD results (normal)

....,....1....,....2....,....3....,....4....,....5....,....6....,....7....,....8 AA MPPRWASLLLLACSLLLLAVPPGTAGPSQPTYPGDDAPVEDLIRFYNDLQQYLNVVTRHRYGRRSSSRVLCEEPMGAAGC PHD_sec HHHHHHHHHHHHHH HHHHHHHHHHHHHHHHH Rel_sec 99344667899999775148557799999899999999487899999999999963455558768757654478789999 SUB_sec LL...HHHHHHHHHHHH..LLLLLLLLLLLLLLLLLLL.HHHHHHHHHHHHHHHH..LLLLLLLLLLLLL..LLLLLLLL P_3_acc eeeebbbbbbbbbbbbbbeeeebee eeeee eeeebeeeebbebbbbb bbbbbbbbe bbeeeeeebbeeeeebeeee Rel_acc 31211425343546874000210210002011012131121533400071058235401101110232000112000210 SUB_acc .....b.b.b.bbbbbb........................b..b...b..bb..bb.......................



GLOBE prediction of globularity


--- 
--- GLOBE: prediction of protein globularity
--- 
--- nexp =    44    (number of predicted exposed residues)
--- nfit =    42    (number of expected exposed residues
--- diff =     2.00 (difference nexp-nfit)
--- =====> your protein appears as compact, as a globular domain
--- 
--- 
--- GLOBE: further explanations preliminaryily in:
---        http://www.columbia.edu/~rost/Papers/1999_globe/paper.html
--- 
--- END of GLOBE


END of results for file t1





Quotes for methods

  1. PredictProtein: PredicProtein: B Rost (1996) Methods in Enzymology, 266:525-539
  2. MaxHom: MaxHom: C Sander R Schneider (1991) Proteins, 9:56-68
  3. MView: MView: N P Brown, C Leroy & C Sander (1998) Bioinformatics, 14:380-381
  4. PHD: B Rost (1996) Methods in Enzymology, 266:525-539
  5. PHDsec: B Rost & C Sander (1993) J. of Molecular Biology, 232:584-599
  6. PHDacc: B Rost & C Sander (1994) Proteins, 20:216-226
  7. GLOBE: B Rost (1998) unpublished




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