Example for prediction-based threading (TOPITS) (default output)


The output consists of the following parts:



The following information has been received by the server:
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
________________________________________________________________________________

b.rost
EMBL, 69012 Heidelberg, Europe
rost@embl-heidelberg.de
prediction-based threading
# 1acf: ACTIN-BINDING PROTEIN
SWQTYVDTNLVGTGAVTQAAILGLDGNTWATSAGFAVTPAQGTTL
AGAFNNADAIRAGGFDLAGVHYVTLRADDRSIYGKKGSSGVITVK
TSKAILVGVYNEKIQPGTAANVVEKLADYLIGQGF
________________________________________________________________________________


The sequence had been interpreted as being:
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
________________________________________________________________________________

>P1; t3 
(#)  1acf: actin-binding protein 
SWQTYVDTNLVGTGAVTQAAILGLDGNTWATSAGFAVTPAQGTTLAGAFNNADAIRAGGF
DLAGVHYVTLRADDRSIYGKKGSSGVITVKTSKAILVGVYNEKIQPGTAANVVEKLADYL
IGQG
________________________________________________________________________________

The resulting prediction is:                             
~~~~~~~~~~~~~~~~~~~~~~~~~~~~
________________________________________________________________________________
--- 
--- ------------------------------------------------------------
--- TOPITS prediction-based threading 
--- ------------------------------------------------------------
--- 
--- TOPITS ALIGNMENTS HEADER: PARAMETERS
--- smin = -1.00 : minimal value of alignment metric
--- smax = 2.00  : maximal value of alignment metric
--- go   = 2     : gap open penalty
--- ge   = 0.2   : gap elongation penalty
--- len1 = 124   : length of search sequence, i.e., your protein
--- 
--- TOPITS ALIGNMENTS HEADER: ABBREVIATIONS
--- RANK         : rank in alignment list, sorted according to z-score
--- EALI         : alignment score
--- LALI         : length of alignment
--- IDEL         : number of residues inserted
--- NDEL         : number of insertions
--- ZALI         : alignment zcore;  note: hits with z>3 more reliable 
--- PIDE         : percentage of pairwise sequence identity
--- LEN2         : length of aligned protein structure
--- ID2          : PDB identifier of aligned structure
--- NAME2        : name of aligned protein structure
--- IFIR         : position of first residue of search sequence
--- ILAS         : position of last residue of search sequence
--- JFIR         : PDB position of first residue of remote homologue
--- JLAS         : PDB position of last residue of remote homologue
--- 
--- TOPITS ALIGNMENTS HEADER: ACCURACY
---              : Tested on 80 proteins, TOPITS found the
---              : correct remote homologue in about 30% of
---              : the cases, detection accuracy was higher
---              : for higher z-scores (ZALI):
--- ZALI>0       : 1st hit correct in 33% of cases
--- ZALI>3       : 1st hit correct in 50% of cases
--- ZALI>3.5     : 1st hit correct in 60% of cases
--- 
--- TOPITS ALIGNMENTS HEADER: SUMMARY
 RANK   EALI LALI IDEL NDEL   ZALI PIDE LEN2  ID2 NAME2                     
    1  95.82  124   15    6   2.60   26  515 2btf A-ACTIN-PROFILIN COMPLEX  
    2  77.58  124   25    6   1.67   11  213 3cla E /III$ CHLORAMPHENICOL A 
    3  76.28  122   57    7   1.61   17  378 7api IFIED ALPHA=1=-*ANTITRYPS 
    4  76.08  121   33    5   1.60   17  243 1eaf YDROLIPOYL TRANSACETYLASE 
    5  75.10  120   66    8   1.55   16  373 2ach HA1 ANTICHYMOTRYPSIN      
    6  73.75  119   57    8   1.48   23  963 2tpr PANOTHIONE REDUCTASE (E.C 
    7  73.63  124   35    7   1.47   15  391 1pbe YDROXYBENZOATE HYDROXYLAS 
    8  73.60  124   73   11   1.47   16  376 1hle SE LEUKOCYTE ELASTASE INH 
    9  73.60  124   73   11   1.47   16  376 1hle SE LEUKOCYTE ELASTASE INH 
   10  73.60  124   73   11   1.47   16  376 1hle RSE LEUKOCYTE ELASTASE IN 
   11  73.60  124   73   11   1.47   16  376 1hle RSE LEUKOCYTE ELASTASE IN 
   12  73.48  124   36    6   1.47   14  180 1ytb TA-BOX BINDING PROTEIN (Y 
   13  73.28  117   28    6   1.46   21  173 1bbp LIN BINDING PROTEIN (/BBP 
   14  73.25  124   36    9   1.45   18  180 1tbp TA-BINDING PROTEIN (TBP,  
   15  72.60  124   14    3   1.42   13  605 1aor DEHYDE FERREDOXIN OXIDORE 
   16  72.50  121   18    5   1.42   20  341 1smr NIN (E.C.3.4.23.15) COMPL 
   17  72.45  121   30    4   1.41   20  394 1phh -*HYDROXYBENZOATE HYDROXY 
   18  72.08  124   49    6   1.39   13  461 3grs UTATHIONE REDUCTASE (E.C. 
   19  71.93  119   57    8   1.39   23  963 2tpr YPANOTHIONE REDUCTASE (E. 
   20  71.78  122   50    6   1.38   17  684 1cgt CLODEXTRIN GLYCOSYLTRANSF 
--- 
--- TOPITS ALIGNMENTS HEADER: PDB_POSITIONS FOR ALIGNED PAIR
 RANK PIDE IFIR ILAS JFIR JLAS LALI LEN2 ID2   
    1   26    1  124  378  514  124  515 2btf  
    2   11    1  124   64  212  124  213 3cla  
    3   17    2  123   77  255  122  378 7api  
    4   17    3  124   87  239  121  243 1eaf  
    5   16    1  120   72  257  120  373 2ach  
    6   23    6  124  659  834  119  963 2tpr  
    7   15    1  124  100  258  124  391 1pbe  
    8   16    1  124   69  263  124  376 1hle  
    9   16    1  124   69  263  124  376 1hle  
   10   16    1  124   69  263  124  376 1hle  
   11   16    1  124   69  263  124  376 1hle  
   12   14    1  124   19  178  124  180 1ytb  
   13   21    1  124   16  153  117  173 1bbp  
   14   18    1  124   19  178  124  180 1tbp  
   15   13    1  124   95  232  124  605 1aor  
   16   20    1  124   13  148  121  341 1smr  
   17   20    1  124  100  247  121  394 1phh  
   18   13    1  124  178  340  124  461 3grs  
   19   23    6  124  177  352  119  963 2tpr  
   20   17    1  124   53  222  122  684 1cgt  
--- 
--- TOPITS ALIGNMENTS: SYMBOLS AND EXPLANATIONS
--- BLOCK 1      : your protein and its predicted 1D structure,
---              : i.e., secondary structure and solvent accessibility
--- line 1       : amino acid sequence (one-letter-code)
--- line 2       : predicted secondary structure:
--- H            : helix
--- E            : strand (extended)
--- L            : other (no regular secondary structure)
--- line 3       : predicted residue relative solvent accessibility
--- B            : buried, i.e., relative accessibility < 15%
--- O            : exposed (outside), i.e., relative accessibility >= 15%
---              : 
--- BLOCKS 1-20  : 20 best hits of the prediction-based threading 
---    ATTENTION : We chose to include all first 20 hit.  However,
---    ATTENTION : most of them will not constitute true remote
---    ATTENTION : homologues.  Instead, all hits with a zscore 
---    ATTENTION : (ZALI) < 3.5 are, at best, rather speculative!
---              : for each aligned protein:
--- line 1       : amino acids conserved between guide (yours) and the
---              : aligned protein (putative homologue)
--- line 1       : sequence of aligned protein
--- line 3       : secondary structure, taken from DSSP (assignment
---              : of secondary structure based on experimental coordinates)
--- line 4       : relative solvent accessibility, taken from DSSP
--- 


--- TOPITS ALIGNMENTS
   1 -  51               ....:....1....:....2....:....3....:....4....:....5
      t3_1               SWQTYVDTNLVGTGAVTQAAILGLDGNTWATSAGFAVTPAQGTTLAGAFNN
                            HHHHHHH     EEEEEEEE     EEEE       HHHHHHHHH   
                         OBOBBBBOBBBBOOOBBBBBBBBOOBOBBBOBOOBOOOOOOBOOBBOBBOO
                           W  Y D NL   G    AAI G     WA   G   TPA    L G    
   1. 2btf         95.82 GWNAYID.NLMADGTCQDAAIVGYKDSpwAAVPGKtiTPAEVGILVGKDRS
                         LLHHHHH.HHHLLLLEEEEEEEELLLLLEEELLLLLLLHHHHHHHLLLLLL
                         BBBBBBBBOBOBOOBBBOBBOOBBOOOBBBBBBBBBOBOBOOOBBBOBBOO
                               D   V      Q         T A S        Q          
   2. 3cla         77.58 QFDELrdELIVWDSVDPQFTVFHQETETfaLSCPYSSDIDqyLSVMERYKS
                         LLHHHLLEEEEELLLEEEEEEEELLLLEEEEELLLLLLHHHHHHHHHHHLL
                         BOOOOOBOOOOOOOBOOOOOOOOOOOBOOOOBBOOBOOOOOBOOOOOOBOB
                           Q    T        T        G   A    F  T             
   3. 7api         76.28  FQELLRTLNQPDSqtTGNGLFLSEghSEAFTVNFGDTEEAKKQINDYvkI
                          HHHHHHHHLLLLLLEEEEEEEEELLLLEEEEELLLLHHHHHHHHHHHHLL
                          BOOOBOBOBBBBBBBBOOOBOOBBOOOBOOOOOBOBOOOOBOBBOOBOOO
                                  L   G     A    DG             A    LA     
   4. 1eaf         76.08   LPDFNSSLAPSGqhIGFAVDTPDGLLVPVIRNVDQKsaEAAELAEKARs
                           LHHHLEEELLLLLLEEELEEELLEEELLEELLHHHLLHHHHHHHHHHHL
                           OOOBOOOOBOOBBOOOOOOBOOBBBOOOBOOBOBOBBBOOOOOOOOBOB
                         S Q    T          A          A    F    A           
   5. 2ach         75.10 SFQHLLRTLNQSSDElgNAMFVKEQLssEAFATDFQDSAAAKKLINDyiKD
                         HHHHHHHHHLLLLLLEEEEEEEELLLLLEEEEELLLLHHHHHHHHHHHLLL
                         OBOOOOOOOOOBOOOBBBBBBBBBBBOBOOBBOBBOOOBOOOOOBOBOOBO
                                       A   A   G  G       G      Q T    A  N
   6. 2tpr         73.75      SNEAFYLDEAPKRALCVgrGGQVDLAYRGDMILrkQLTEQLRANgn
                              HHHHLLLLLLLLEEEEELLLLEEEEEELLLLLLLHHHHHHHHHLLL
                              BOBOOOBOOOOOOBOBOBOOOOBBBBBOOOOBBBBOBOOBOOOOOO
                           QT V   L G   V QAA          T          G         
   7. 1pbe         73.63 YGQTEVTRDLmgATTVYQAAEVrqGERPYVTFERDGedGFHGISRQSIPAE
                         LLHHHHHHHHHLLEEELLLEEEELLLLLEEEEEELLELLLLLHHHHLLLHH
                         OBBBBBOBOBOOBBBOBOOOOBOOOBOOBOOOOOOOBBBBBBOOOOOOOBO
                           Q          GA           N    S  F   P       G    
   8. 1hle         73.60 RFQS.LNADINKPGalANRLYGEKTYnaELASVDFQQAPEdnEWVKGQTEg
                         HHHH.HHHHHLLLLLEEEEEEEELLLLLEEEEELLLLLHHHHHHHHHHLLL
                         OBOOOOOOOOOBOOOOBOOOBOBOBBBOOBBOOBOOOBOOOOOBBOOOOOO
                           Q          GA           N    S  F   P       G    
   9. 1hle         73.60 RFQS.LNADINKPGalANRLYGEKTYnaELASVDFQQAPEdnEWVKGQTEg
                         HHHH.HHHHHLLLLLEEEEEEEELLLLLEEEEELLLLLHHHHHHHHHHLLL
                         OBOOOOOOOOOBOOOOBOOOBOBOBBBOOBBOOBOOOBOOOOOBBOOOOOO
                           Q          GA           N    S  F   P       G    
  10. 1hle         73.60 RFQS.LNADINKPGalANRLYGEKTYnaELASVDFQQAPEdnEWVKGQTEg
                         HHHH.HHHHHLLLLLEEEEEEEELLLLLEEEEELLLLLHHHHHHHHHHLLL
                         OBOOOOOOOOOBOOOOBOOOBOBOBBBOOBBOOBOOOBOOOOOBBOOOOOO
                           Q          GA           N    S  F   P       G    
  11. 1hle         73.60 RFQS.LNADINKPGalANRLYGEKTYnaELASVDFQQAPEdnEWVKGQTEg
                         HHHH.HHHHHLLLLLEEEEEEEELLLLLEEEEELLLLLHHHHHHHHHHLLL
                         OBOOOOOOOOOBOOOOBOOOBOBOBBBOOBBOOBOOOBOOOOOBBOOOOOO
                                                    T A     A               
  12. 1ytb         73.48 RLDLKTVALHanPKRFAAVIMRIREPKTTALIFAsaKSEDDSKLASRKyfA
                         LLLHHHHHHHLLLLLLLLEEEEELLLLEEEEELLLELLHHHHHHHHHHHLL
                         OOOBOOBOBOBBOBOBOOBOBOBBOOOOOOOOOOOOBOBOBOBOBOBOBOB
                                 N V        A     G     S         GT        
  13. 1bbp         73.28 NFDWSNYhnSVEKYGKCGWAEYTPEGKSVKVSNYHVIHGkeGTAYPVGDSK
                         LLLHHHLLLLLLLLLEEEEEEEEELLLLEEEEEEEEELLEEEEEEELLLLL
                         BOOOBOOOBBBBBOOOOOOOOOBBBBBOOOOBBBBBBOOOOOOBOBOBOBO
                              V        AV   A     G    T A            A     
  14. 1tbp         73.25 RLDltVALHARnfAAVitTALIFASGKMVVTGAKSEDDSKlsRKYARIIQK
                         LLLHHHHHHHLLLLLEEEEEEELLLLEEEEEEELLHHHHHHHHHHHHHLLL
                         OOOBBBBBOBOOBOOBOOOOOBBOOBOOBBBBOBOBOBOBOBBBBBOOOOO
                                    G  A                                    
  15. 1aor         72.60 GGYFGAELKFAGYDAIVVevYIYIKDEHIEIRDASHIWGKKVSETEATIRK
                         LLLHHHHHHHLLLLEEEEEEEEEEELLEEEEEELLLLLLLLHHHHHHHHHH
                         OBOOBOOOOOOOOOBBBBBOBBBBBBBBOBBBBBBOBBBBBBBBBOBBBBB
                             Y      GT   T   I     N W  S            L      
  16. 1smr         72.50 LNSQYYGEIGIGTPPQTFKVIFDtsANLWVPSTKCSRLYLACGilYESSDS
                         LLLEEEEEEEELLLLEEEEEEEELLLLEEEEELLLLLLLHHHHHLELHHHL
                         BOBOOOBBOOBBBBBBBBBOBOOBOOOBOOBBBBOBOBOBOOBOBOBBOBO
                           QT V   L   GA T A  L LD    A   GF     Q          
  17. 1phh         72.45 YGQTEVTRDLmaCGATTvaEvlRLDCDYIAGCDGFHGISRQSIPAER...L
                         LLHHHHHHHHHLLLLLEEEEEEEEELLEEEELLLLLLLLHHHLLHHH...L
                         OBOOOOOOOOBOOOOBOOOOBBBBBBBBOOOOBOOOBOBOOOOOOOBBOBB
                              V                                    T       N
  18. 3grs         72.08 AGYIAVEMAGILSALGSKTSLMIRHDKVL.....RSFDSMISTNCTEELEN
                         LLHHHHHHHHHHHHLLLEEEEELLLLLLL.....LLLLHHHHHHHHHHHHH
                         OOOOBBOOBOOOOOBBOBOOOOBOOOOBOOBBBBOOBBBOOOOBOBBOOOO
                                       A   A   G  G       G      Q T    A  N
  19. 2tpr         71.93      SNEAFYLDEAPKRALCVgrGGQVDLAYRGDMILrkQLTEQLRANgn
                              HHHHLLLLLLLLEEEEELLLLEEEEEELLLLLLLHHHHHHHHHLLL
                              BOBOOOBOOOOOOBOBOBOOOOBBBBBOOOOBBBBOBOOBOOOOOO
                          WQ      L  T  VT  A  G              T A    L      
  20. 1cgt         71.78 DWQGLInsDLGVtsGVTNTAYHGYWARDFKKTNPYFGTMADFQNLITTA.H
                         LHHHHHHHHHLLLLLEEELLLLLLLEEEEEEELLLLLLHHHHHHHHHHH.H
                         OOBOOBBOBOBBBBBBBBBOOOOBBOBBOOBOOOOBBOOBBOBBBOBBBBB
--- 
--- TOPITS ALIGNMENTS CONTINUED 
--- 
  51 - 101               ....:....1....:....2....:....3....:....4....:....5
      t3_1               NADAIRAGGFDLAGVHYVTLRADDRSIYGKKGSSGVITVKTSKAILVGVYN
                             EEE EEEEEEEEEEEEEE   EEEEE     EEEEE  EEEEEEEE 
                         OOOOBOBOBBOBBBBOBBBBOOOOOOBOBOOOOOBBBBBOBBOBBBBBBBO

                                 GG          L            S G ITV T K        
   1. 2btf         95.82 SsnGLTLGGQKCSVIRDSLLQDGEFTMDLRTKSTgnITvmTAKTLVLLMGK
                         LLHLEEELLEEEEEEEELLLLLLLLEEEEEELLLLEEEEELLLEEEEEEEL
                         OBOOOBOBOOBBOOOOBOOOOOOBOOBBBOOOOOOOOOBBBBBBBOBOBOO
                                          V                  IT        V V  
   2. 3cla         77.58 SDTKlpENHLNISALPWVNFDSFNLNVANFTDyaPIITMAKYqpLSVQVHH
                         LLLLLLLLEEEEEEELLLLLLLLLLLLLLLLLLLLEEEEELLEEEEEEEEL
                         BOBBBBBOOOOOOBBBBOBOOBBOBBBBBBBBOOOOOOOBOOOOOOOOOOO
                           D       D A V Y     D               VK S   L   Y 
   3. 7api         76.28 IVDLVKELDRdfALVNYIFFKgdTEEEDFHVDQVTTVKvkLSSWVLLMKYL
                         LLLLLLLLLLLEEEEEEEEEEELLEEEEEELLLLLEEEELLLEEEEEEEEL
                         OOOOOBBBBBBBOBOOOOOOBBBOOOOBOOOOBOBOOBBBBBBBBBBBBBB
                          ADA     F         L     S                         
   4. 1eaf         76.08 saDAMQGACFTISSLgvAILGVSKASMQPVWDGKAFQPRLM.LPLSLSYDH
                         LHHHHLLLLEEEEELLLEEEEELLLEEEEEELLLLEEEEEE.EEEEEEEEL
                         BOOOOBBOBBBOBBBBOOOOOOBOOBOBOOOOOOOOBOOOBOOOOOOOOOO
                           D      F  A V    L             S V   K     L     
   5. 2ach         75.10 DLDslVNYIFFKAkvPMMSLHHLTIPYFRDEELstVVELkgNASALFILPD
                         LLLLEEEEEEEEEEEEEEEEEEEEEEEEEELLLLEEEEEELLEEEEEEEEL
                         OOOOBBBBBBBBBOOOOOBOBBOBBOOBBOOOBBBBBBBBBBBBBBBBBOO
                         NAD  R   F  A   YV   A  R         G I V  SK      Y 
   6. 2tpr         73.75 nADGTRHVVFEsaEADyvVMLAIGRVPRSQtaKNGAIKVDasKTNVDNIyd
                         LLLLLEEEEELLLEEEEEEEELLLEEELLLLLLLLLELLLLLELLLLLEEL
                         OOBOOOOOOOOBBBBOOBOBOBBBOBBOBBBOBBBBBOOOOOOOBOBBBBB
                                                   IY                       
   7. 1pbe         73.63 ERLKVFERVYPFGWLGLLADTPPVShiYANHPRGFAlqRSATRSRYYVQvt
                         HHLEEEEEEEEEEEEEEEELLLLLLLEEEELLLLLEEEEELLEEEEEEEEL
                         OBOOOOOOBBBBBBOBOOOOOOBOOOBOOBBOBBOOBBOOBOOOBOOOOOB
                                G   L    Y                    TVK     L   Y 
   8. 1hle         73.60 gpELLVKgkLVLVNAIYFKGNWQQkdAPFRLNKKDTKTVKMMYqvLELPYQ
                         LLLLLLLLEEEEEEEEEEEEEELLLEEEEELLLLLEEEEEEEEEEEEEEEL
                         OBOBOOBOOOBOOOOOOOOBBBBOBOOOOOBOOBBOOBOOOBOOOOBBOOB
                                G   L    Y                    TVK     L   Y 
   9. 1hle         73.60 gpELLVKgkLVLVNAIYFKGNWQQkdAPFRLNKKDTKTVKMMYqvLELPYQ
                         LLLLLLLLEEEEEEEEEEEEEELLLEEEEELLLLLEEEEEEEEEEEEEEEL
                         OBOBOOBOOOBOOOOOOOOBBBBOBOOOOOBOOBBOOBOOOBOOOOBBOOB
                                G   L    Y                    TVK     L   Y 
  10. 1hle         73.60 gpELLVKgkLVLVNAIYFKGNWQQkdAPFRLNKKDTKTVKMMYqvLELPYQ
                         LLLLLLLLEEEEEEEEEEEEEELLLEEEEELLLLLEEEEEEEEEEEEEEEL
                         OBOBOOBOOOBOOOOOOOOBBBBOBOOOOOBOOBBOOBOOOBOOOOBBOOB
                                G   L    Y                    TVK     L   Y 
  11. 1hle         73.60 gpELLVKgkLVLVNAIYFKGNWQQkdAPFRLNKKDTKTVKMMYqvLELPYQ
                         LLLLLLLLEEEEEEEEEEEEEELLLEEEEELLLLLEEEEEEEEEEEEEEEL
                         OBOBOOBOOOBOOOOOOOOBBBBOBOOOOOBOOBBOOBOOOBOOOOBBOOB
                          A           G   V       S Y      G I VK     L  V  
  12. 1ytb         73.48 AAKFTDFKIQNIVGSCDVKFPigTFSSYEPELFPGLIyvKPKIVLLiiVLT
                         LLLLEEEEEEEEEEEEELLLLELLLEELLLLLLLLEEELLLLLEEEEEEEE
                         BOOOOOOBOOBBOOBBOOBOOOBOOOBOBOBOBOOBOBBOOOOOOOOOOBO
                             I  GG     V  V        I GK         K           
  13. 1bbp         73.28 KIGKIYhgGVTKENVFNVLSTDNKNYIIgkYDEDK....KGHQDFVWVLSR
                         LLLEEEELLEEEEEEEEEEEELLLLEEEEEEELLL....LEEEEEEEEEEL
                         OOOOOOBOOOOOOBOBBBOOBBOBOOOOOBBBBOOBOBOOBOBBBBBOBOO
                            A     F          R    S Y      G I VK     L  V  
  14. 1tbp         73.25 KIgaAKFTDFKIQNIVGScirhGTFSSYEPELFPGLimVKPKIVLLiiVLT
                         LLLLLLLLLLEEEEEEEEEELLLLLEELLLLLLLLEEELLLLEEEEEEEEE
                         OOOBOOOOOOBOOBBOOBBOOOBOOOBBBOBOOOOOOBBOOOOOOOOOBBO
                                      GV       D     G  G   V   K  KAI V    
  15. 1aor         72.60 KEVGSEKVKIASIgvKFAAIMNDGHRAAGRGGVGAVMGSKNLKAIAVEGSK
                         HHHLLLLLEEEELLLLLELEEELLLEEELLLLHHHHHHHLLEEEEEEELLL
                         BBBBBBOBBBBBOBBBBBBBOOOOBOBOBOBOOBBBOBBBBBBBBBOOBBO
                                G  D    HY   R             G     T      GV  
  16. 1smr         72.50 SSSYMENG..DDFTIHYGSGRVKGFLSQDSVTVGGITVTQTFGEVTqgVLG
                         LLLLEEEE..EEEEEEELLEEEEEEEEEEEEEELLEEEEEEEEEEEEEEEE
                         OBOOOOBOBOBOOOOOOOOOBOOBOBOOBOOBBOOOOOBOOBBBBBBOOOB
                              R   F   G    T       IY             S         
  17. 1phh         72.45 LKVFERVYPFGWLGLLADTPPVSHELIYANHPRGFALCSQRSATRSRYYVQ
                         LEEEEEELLLEEEEEEELLLLLLLLEEEEEELLEEEEEEEEELLEEEEEEE
                         BOBOOOOOOBOOOBOOOOBBOBBOOBBBBOOOOOOBOOOOOOBBBBBOBOO
                         NA      G     V   T   D             I          G Y 
  18. 3grs         72.08 NAGvvKesGLEVSMVtvMTMIPDVDCLLwtDDKGHIIVDEFQNTNVKGIyg
                         HLLLEEELEEEEEEEEEEEEEEEELEEEEELLLLLELLLLLLELLLLLEEL
                         OOBBOBOOOOOOOBOOBOOOBOOOOOOOOOOBBOOOOOBBOOBBOOOBBBO
                         NAD  R   F  A   YV   A  R         G I V  SK      Y 
  19. 2tpr         71.93 nADGTRHVVFEsaEADyvVMLAIGRVPRseVAKNGAIKVDasKTNVDNIyd
                         LLLLLEEEEELLLEEEEEEEELLLEEELLLELLLLLELLLLLELLLLLEEL
                         OOBOOOOOOOOBBBBOOBOBOBBBOBBOBBBOBBBBBOOOOOOOBOBBBBB
                          A  I     D A  H   L        G                L     
  20. 1cgt         71.78 HAKGIKI.VIDFAPNHTSplYDNGTLVGGYTNDTNGYFHHNGGsnLYDLAD
                         HHLLLEE.EEEELLLEEEEEEELLEEEELLLLLLLLLELLLLELEELLEEE
                         BBBBBOOOOOOBOOOBBBBBBOOOBBOBBBOBBBBBBBOBOOBOOOOOOBB
--- 
--- TOPITS ALIGNMENTS CONTINUED 
--- 
 101 - 124               ....:....1....:....2....:....3....:....4....:....5
      t3_1               NEKIQPGTAANVVEKLADYLIGQG
                                HHHHHHHHHHHHHH   
                         OOOOOOOOBOOBBOOBBOBBBOOO

                           E    G         A  L    
   1. 2btf         95.82 KEGVHGGMINKKCYEMASHLRRSQ
                         LLLLLHHHHHHHHHHHHHHHHLLL
                         OOOBBBBBBOOBBBBBBBBOOOOO
                                  A     L        
   2. 3cla         77.58 HAVCDGFHVARFINRLQELCNSKL
                         LLLLLHHHHHHHHHHHHHHHLLLL
                         OOOOOOOBOOOBOBOOOOOOOOOO
                               G        L    I  
   3. 7api         76.28 LGNadEGKLQHLENELTHDIITK
                         LLLELLLLHHHHHHHLLHHHHHH
                         BOOOBBOBBBOBBOOBBOOBBOO
                            I    AA     L D L    
   4. 1eaf         76.08 HRVINGAAAARFTKRLGDLLADIR
                         LLLLLHHHHHHHHHHHHHHHHLHH
                         OOOOOOOOOOOOOOOOOOOOOOOO
                                  A       D L
   5. 2ach         75.10 DQDKMEEVEaeTLKRWRDSL
                         LLLLHHHHHHHHHHHHHHHL
                         OOOOOBBOOBBOBBBOBOOO
                                 A N      D      
   6. 2tpr         73.75 dRVMLTPVAINEGAAFVDTVFANK
                         LLLLLHHHHHHHHHHHHHHHHLLL
                         BBBOOBBOBBBOBBBBBBBOBOOO
                          EK            L   L   G
   7. 1pbe         73.63 tEKVEDWSDERFWTELKARllVTG
                         LLLHHHLLHHHHHHHHHHHLLLLL
                         BBBBOBOOOOBBBBBBBBBBOBOO
                           KI          KL        
   8. 1hle         73.60 QGkiEDESteKilDKLREWTKPEN
                         LLLLLLLLLHHHHHHHHHHHLHHH
                         BBBBOBOOOOBBBBOBBBOBBOOO
                           KI          KL        
   9. 1hle         73.60 QGkiEDESteKilDKLREWTKPEN
                         LLLLLLLLLHHHHHHHHHHHLHHH
                         BBBBOBOOOOBBBBOBBBOBBOOO
                           KI          KL        
  10. 1hle         73.60 QGkiEDESteKilDKLREWTKPEN
                         LLLLLLLLLHHHHHHHHHHHLHHH
                         BBBBOBOOOOBBBBOBBBOBBOOO
                           KI          KL        
  11. 1hle         73.60 QGkiEDESteKilDKLREWTKPEN
                         LLLLLLLLLHHHHHHHHHHHLHHH
                         BBBBOBOOOOBBBBOBBBOBBOOO
                             Q        E     L    
  12. 1ytb         73.48 TGAKQREEIYQAFEAIYPVLSEFR
                         EEELLHHHHHHHHHHHHHHHHHLE
                         OOBOBOOOBOBOBOBOOBOBOOOO
                           K   G A   VE    YLIG  
  13. 1bbp         73.28 RSKVLTGEAKTAVE...NYLIGSP
                         LLLLLLHHHHHHHH...HHHHHLL
                         OOBOOBOBOOBOOOOOOOOOOOBB
                             Q        E     L    
  14. 1tbp         73.25 TGAKQREEIYQAFEAIYPVLSEFR
                         EEELLLHHHHHHHHHHHHHHHHLE
                         OOBOBOOOBOBOBBBBOBOBOOOO
                                    VV      L    
  15. 1aor         72.60 KTVPIAdkFMLVVREKVNKLRNDP
                         LLLLLLLHHHHHHHHHHHHHHHLH
                         OOOBOOOOOOOBOBBBBOBOBBOO
                              P  A   V    D    QG
  16. 1smr         72.50 GMGF.PAQAVGGVTPVFDHILSQG
                         ELLL.HHHLHHHLLLHHHHHHHLL
                         BBBBOBBBBBOOOBOBOBOBOOOO
                                      E     L    
  17. 1phh         72.45 QVPLTEKVEDWSDERFWTELKARL
                         EELLLLLHHHLLLHHHHHHHHLLL
                         OOOBBBBBBBBBBBBBBBBBOBOO
                                 A     KLA  L    
  18. 3grs         72.08 gKALLTPVAIAAGRKLAHRLFEYK
                         LLLLLHHHHHHHHHHHHHHHHLLL
                         OOBOOBBBBBBOBBBBBBBOBOOO
                                 A N      D      
  19. 2tpr         71.93 dRVMLTPVAINEGAAFVDTVFANK
                         LLLLLHHHHHHHHHHHHHHHHLLL
                         BBBOOBBOBBBOBBBBBBBOBOOO
                                T               G
  20. 1cgt         71.78 DFNHNNATIDKYFKDAIKLWLDMG
                         EELLLLHHHHHHHHHHHHHHHHLL
                         BBBBBBBBBBBBBBBOBOOOOBOO
--- 
--- TOPITS ALIGNMENTS END
---